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Am J Case Rep ; 22: e928421, 2021 Feb 05.
Artículo en Inglés | MEDLINE | ID: covidwho-1068018

RESUMEN

BACKGROUND High-frequency percussive ventilation (HFPV) is a method that combines mechanical ventilation with high-frequency oscillatory ventilation. This report describes 3 cases of patients with severe COVID-19 pneumonia who received intermittent adjunctive treatment with HFPV at a single center without requiring admission to the Intensive Care Unit (ICU). CASE REPORT Case 1 was a 60-year-old woman admitted to the hospital 14 days after the onset of SARS-CoV-2 infection symptoms, and cases 2 and 3 were men aged 65 and 72 years who were admitted to the hospital 10 days after the onset of SARS-CoV-2 infection symptoms. All 3 patients presented with clinical deterioration accompanied by worsening lung lesions on computed tomography (CT) scans after 21 days from the onset of symptoms. SARS-CoV-2 infection was confirmed in all patients by real-time reverse transcription-polymerase chain reaction (RT-PCR) assay from nasal swabs. All 3 patients had impending respiratory failure when non-invasive intermittent HFPV therapy was initiated. After therapy, the patients had significant clinical improvement and visibly decreased lung lesions on followup CT scans performed 4-6 days later. CONCLUSIONS The 3 cases described in this report showed that the use of intermittent adjunctive treatment with HFPV in patients with severe pneumonia due to infection with SARS-CoV-2 improved lung function and may have prevented clinical deterioration. However, recommendations on the use of intermittent HFPV as an adjunctive treatment in COVID-19 pneumonia requires large-scale controlled clinical studies. In the pandemic context, with a shortage of ICU beds, avoiding ICU admission by using adjunctive therapies on the ward is a useful option.


Asunto(s)
COVID-19/terapia , Ventilación de Alta Frecuencia , Anciano , COVID-19/complicaciones , Deterioro Clínico , Tos/terapia , Tos/virología , Disnea/terapia , Disnea/virología , Femenino , Hospitalización , Humanos , Pulmón/diagnóstico por imagen , Pulmón/virología , Masculino , Persona de Mediana Edad , Terapia por Inhalación de Oxígeno , Insuficiencia Respiratoria/prevención & control , Tomografía Computarizada por Rayos X
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